Weekly selection of intriguing scientific articles in the field of Hematology focusing on: stem cells & aging, hematopoietic transplant and acute myeloid leukaemia.
🧫 HEMATOPOIETIC STEM CELLS & AGING
💡 Aberrant engagement of P-selectin drives hematopoietic stem cell aging in mice. Yang et al., Nature Aging. 2025.
- The surface marker P-selectin (CD62P) was used to identify HSCs characterised by an “aged” molecular and functional profile.
- P-selectin engagement could suppress ageing-associated gene expression programs, showing potential for HSCs regeneration.
💊 HEMATOPOIETIC TRANSPLANT
cMPL-based purification and depletion of human hematopoietic stem cells: implications for pretransplant conditioning. Araki et al., Blood. 2025.
- The authors identify cMPL (thrombopoietin receptor) on human CD34+ stem cells as a novel target to enhance pretransplant conditioning regimen.
- Proof of concept studies in macaques showed the safety of the approach while achieving effective engraftment of donor stem cells without the need of conventional bone marrow ablative regimens.
🩸 ACUTE MYELOID LEUKEMIA
Blood-based proteomic profiling identifies OSMR as a novel biomarker of AML outcomes. Reville et al., Blood. 2025.
- The authors performed a blood-based proteomic profiling of 543 patients with newly diagnosed AML and then generated a 8-proteins panel defining a new prognostic score for overall survival.
- The study highlights the importance of robust blood-based biomarkers for risk stratification and prognostic significance in newly diagnosed AML.
